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Website Engene Inc.

Engene Inc.

Job Responsibilities

enGene Inc. is a high growth biotechnology company developing a robust, proprietary non-viral vector platform to deliver genes to various epithelial tissues. The vector system can be administered to the intestine via the oral or enema route, or the bladder via instillation. enGene is developing its unique gut optimized gene delivery formulation into an orally available “Gene Pill™”, which has the potential to be a platform for oral delivery of a wide range of therapeutic protein drugs. The Company’s primary focus is to apply its technology to enable localized delivery of therapeutic proteins to the gut and other epithelial tissues for treating various disorders.

enGene Inc. is currently seeking a qualified and motivated candidate who will play a key role in the Formulation group. In collaboration with project leaders, the Research Scientist – Formulation will provide expertise to a team responsible for developing and optimizing formulation to support the pipeline development and production of nanoparticle gene therapy drug products. The Research Scientist – Formulation should have advanced knowledge of in polymer sciences, nanoparticles and formulation with working knowledge of gene therapy and molecular biology. This position reports to the Manager of Formulation.
The candidate will work in a dynamic, fast-paced and highly collaborative environment, as well as perpetuate the company culture that promotes our values (Patient-focused, Integrity, Innovation and Teamwork).

The Research Scientist- Formulation will:
• Apply technical and functional knowledge to design experiments, and independently complete work within own project team, working on multiple sub- projects in parallel
• Plan and conduct relevant characterization studies in order to develop formulation and establish process requirements for initial manufacturing process
• Optimize formulations, and study new raw materials and compositions
• Develop product specifications by evaluating properties of raw materials and formulations
• Conduct studies evaluating active drug and excipient interactions
• Act as a technical expert and scientific resource within own project team/ discipline, providing formal/informal mentoring within project team as required
• Analyze statistical data with limited supervision on projects consisting of moderate to high technical risk
• Initiate and lead the generation of technical documents/reports
• Follow documentation practices in accordance with Quality requirements
• Prepare and present Presentations to colleagues on regular basis
• Attend technical meetings and provides substantial scientific input
• Use own scientific judgment to apply and adapt standard methods and techniques with
increased independence by applying prior work experience
• Work independently under minimal supervision to complete assignments using
knowledge and work experience; proactively gather input from colleagues to assist
with novel (to them) aspects of the job
• Frequently develop and create novel processes and hypotheses using new ideas and
• Identify and develop scientific activities / projects to support short-term operational
• Influence at the project team level
• Work with Contract Manufacturing Organization (CMO) and support formulation
laboratory activities for early Formulation development of solid oral dosage forms of
new chemical entities or new dosage forms for gene therapy drug
• Working with the CMC team, providing technical assistance to cross functional areas
in all aspects of oral product formulation
Skills and Experience:
• Preferably with experience in early phase drug development and the use of relevant
physicochemical properties for solution and/or solid dosage form development, polymer
sciences, nanoparticle formulations and molecular biology techniques
• Ability to work in a team environment and communicate effectively to facilitate meeting
• Excellent organizational and analytical skills
• Excellent oral and written communication skills in English, French is an asset

• BSc with a minimum of 6 years of relevant experience
• MSc with a minimum of 3 years of relevant experience
• PhD with a minimum of 1-3 years of relevant experience

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