Mainstreaming
Gene Therapy

DEVELOPING LOCALLY ADMINISTERED, NON-VIRAL
GENE THERAPIES FOR UNDERSERVED DISEASES

At enGene, we are at the vanguard of a new era in genetic medicine: Our novel gene delivery platform offers localized delivery of multiple gene cargos directly to mucosal tissues and other organs — potentially overcoming the limitations of viral-based gene therapies and advancing gene therapy beyond rare genetic diseases into the mainstream of clinical practice.

3D illustration of blue nanoparticles

DDX® Platform

Our breakthrough Dually Derivatized Oligochitosan® (DDX) platform opens possibilities for streamlining the use of genetic medicines in the treatment of serious diseases, especially diseases afflicting mucosal tissues.

The medicines we are developing are designed to transform mucosal cells into therapeutic production ‘factories’ that produce proteins and RNAs in the microenvironment of disease, creating a potent yet local therapeutic effect while avoiding the immunogenicity and systemic effects associated with viral-based genetic medicines.

DISCOVER MORE ABOUT DDX TECHNOLOGY

EG-70

Non-viral gene therapy for NMIBC

EG-70 (detalimogene voraplasmid) is a non-viral immunotherapy in development to treat non-muscle invasive bladder cancer (NMIBC), a disease with a significant patient burden, high clinical needs, and massive healthcare system economic impact.

Based on its preliminary efficacy and safety profile and ease of administration by urologists, we believe EG-70 can benefit patients across a wide variety of clinical settings.

LEARN ABOUT EG-70 AND THE LEGEND STUDY
older black female and male couple walking in the woods with his arm around her

We are enGeneers

Boldly focused on patient needs

Our scientists meticulously refined the DDX platform with a singular focus: to develop practical yet life-changing therapies for patients with underserved diseases. To advance our mission, we’ve assembled a team of industry leaders and innovators.

MEET OUR TEAM
Jason Hanson, CEO & Director
Alex Nichols, President & COO

Seeking fearless people deeply committed to patient needs. Let’s forge a new path in genetic medicine.

JOIN US

Anthony Cheung, co-founder and CTO
Jim Sullivan, Chief Scientific Officer
Richard Bryce, Chief Medical Officer

We are enGeneers

Boldly focused on patient needs

Our scientists meticulously refined the DDX platform with a singular focus: to develop practical yet life-changing therapies for patients with underserved diseases. To advance our mission, we’ve assembled a team of industry leaders and innovators.

MEET OUR TEAM
Jason Hanson, CEO & Director
Alex Nichols, President & COO
Anthony Cheung, co-founder and CTO
Jim Sullivan, Chief Scientific Officer
Richard Bryce, Chief Medical Officer

Seeking fearless people deeply committed to patient needs. Let’s forge a new path in genetic medicine.

JOIN US